Revista de investigación y terapia con células madre

Abstracto

Live Fetal Stem Cells Therapy, Anti-Neu5Gc Responses and Impact on Human Heart, Brain and Immune System

Balbir Bhogal, Daniel Royal, Robert Boer, Ann Knight

Fetal stem cells used for clinical applications in humans can cause xenogenic immune reactions and impact vital organs by immune dysregulation. Animal stem/fetal cells express glycan antigens, such as Neu5Gc. Humans do not produce these antigens. Two major sialic acids are described in mammalian cells, Neu5Gc, the N-glycolylneuraminic acid, and Neu5Ac the N-acetylneuraminic acid. Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by a hydroxylic group addition catalyzed by cytidinemonophospho-N-acetyl-neuraminic acid hydroxylase-Neu5Ac hydroxylase enzyme (CMAH). CMAH was inactivated by a 92 base pairs deletion over 2 million years ago and is non-functional in humans, Neu5Gc as well as the peptides derived from fetal cells is remarkably immunogenic for humans and promotes inflammation, arthritis, cancer. Accumulating evidence shows that xenotransplantation of animal stem cells results in inflammation autoimmune responses and immune-rejection and may cause death. Here we highlight the serious deleterious effects of the presence of Neu5Gc antigen in animal fetal cells and the effects of presence and absence of Neu5Gc antibodies in humans acquired through the consumption of animal products. There are many reports of immune reactions to animal stem cells and their derivatives. Insect biterelated anti-alpha-gal and anti-Neu5Gc antibodies, and those induced by animal cells, cause “immune enhancement” and serious allergic reactions and or immune-pathology leading to irreversible damage to vital organs in the human body. Therefore needless to say that the use of animal stem cells and their derivatives being marketed as nutritional supplements are harmful for human use and should not be used either as oral supplements or as peptide injections. There is no evidence of their safety or efficacy for treating disease conditions or for their anti-aging effects. Neu5Gc (xeno-antigen), are produced by Animal Stem/fetal Cells and the peptides derived from them. Remarkably, Neu5Gc is a xeno-antigen for humans, and promote inflammation, arthritis, cancer, and xeno-transplantation of animal stem cells can result in inflammation autoimmune responses and immune-rejection (GVHD) and death.