Pharmaceutica Analytica Acta

Abstracto

Natural Therapies in Rheumatoid Arthritis

Nidhi Sachan*, Pramod Kumar Sharma, Md. Aftab Alam

Rheumatoid arthritis is an autoimmune disorder that is categorized by systemic inflammation of synovial joints. There are various factors which are involve in the pathophysiology of RA, i.e. influx of B-cells, critical role of T-cells which initially attacks on synovial joints and many more. Oxygen metabolism generating Reactive Oxygen Species (ROS) and activating phagocytic cells plays an important role in the pathophysiology of RA. The progression cycle of oxidative reactions plays a significant role in case of RA. Reactive ions leads the cause include superoxide anions, hydrogen peroxide, hydroxyl radical, nitric oxide and hypochlorous acid. These ROS and RNS species setups repeated reactions disturbing the whole process of the immune system and genetic integrity causing RA. Thus, review about the detailed role of oxidant molecules involved in the pathophysiology of RA and the role of numerous antioxidants therapies to mitigate these stresses.