Revista de carcinogénesis y mutagénesis

Abstracto

Novel Therapeutics for Adverse Effects of Antitumor Therapy: The Promise of Multicomponent, Traditional Japanese Herbal Remedies

Toru Kono, Hiroshi Takeda, Mitsuo Shimada, Yoshio Kase and Yasuhito Uezono

In contrast to conventional single-target drugs, multi-component Kampo medicines are designed to achieve therapeutic effects through multiple drug targets. This article will discuss recent advances in mechanistic studies and the clinical effects of five representative Kampo formulations (hangeshashinto, daikenchuto, goshajinkigan, yokukansan and rikkunshito) for the treatment of adverse effects caused by anticancer drugs such as oral mucositis, diarrhea, neurotoxicity and abnormal behavior, for which western pharmaceuticals fail to adequately address.