indexado en
- Abrir puerta J
- Genamics JournalSeek
- CiteFactor
- Cosmos SI
- cimago
- Directorio de publicaciones periódicas de Ulrich
- Biblioteca de revistas electrónicas
- Búsqueda de referencia
- Universidad Hamdard
- EBSCO AZ
- Directorio de indexación de resúmenes para revistas
- OCLC-WorldCat
- Convocatoria de búsqueda
- erudito
- CAMINO
- Biblioteca Virtual de Biología (vifabio)
- Publón
- Fundación de Ginebra para la Educación e Investigación Médica
- Google Académico
Enlaces útiles
Comparte esta página
Folleto de diario
Revistas de acceso abierto
- Administración de Empresas
- Agricultura y Acuicultura
- Alimentación y Nutrición
- Bioinformática y Biología de Sistemas
- Bioquímica
- Ciencia de los Materiales
- Ciencia general
- Ciencias Ambientales
- Ciencias Clínicas
- Ciencias farmacéuticas
- Ciencias Médicas
- Ciencias Veterinarias
- Enfermería y Cuidado de la Salud
- Genética y Biología Molecular
- Ingeniería
- Inmunología y Microbiología
- Neurociencia y Psicología
- Química
Abstracto
Efecto antioxidante y hepatoprotector del betacaroteno sobre el daño hepático inducido por paracetamol en ratas
Morakinyo AO, Iranloye BO, Oyelowo OT, Nnaji J
The role of oxidative stress on the hepatic damage caused by acetaminophen (APAP) and the possible protective effects of beta-carotene supplement against this damage were investigated. The rats were randomly divided into four groups: control, APAP, beta-carotene, and APAP1beta-carotene. The control group received distilled water while APAP (750 mg/kg body weight), beta-carotene (10 mg/kg/day body weight) (BC) were administered to the other groups accordingly. The serum glutamate oxalate transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) as well as serum alkaline phosphatase (SAP) levels of APAP group were significantly increased when compared with the control (p , 0.01). This was ameliorated by the administration of beta-carotene. The SOD, GSH, and CAT levels of the APAP groups which were significantly decreased (p , 0.001) when compared with the control. There was a boost in the antioxidant level after the application of BC. The reverse was the case in the malondialdehyde (MDA) activity. The study showed that BC will ameliorate the damaging effect of APAP on liver tissues.