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Abstracto
Clove Oil Emulsified Buccal Patch of Serratiopeptidase for Controlled Release in Toothache
Shende PK, Gaud RS, Bakal R and Yeole Y
The objective of this work was to formulate and characterize clove oil emulsified buccal patch of serratiopeptidase to offer their combinational controlled release actions in dental pain. The buccal patches were prepared by two methods 1. Adding serratiopeptidase and clove oil in alcoholic solution of hydroxypropyl methylcellulose (HPMC) and Eudragit. 2. Emulsification of clove oil in aqueous serratiopeptidase solution and then dispersed in mixture of polymeric solution of HPMC and Eudragit. Scanning electron microscopy (SEM) of patches showed uniform distribution of w/o emulsion of serratiopeptidase and clove oil; and regular surface of patches. Entrapment efficiencies of serratiopeptidase and clove oil were found to be significant. In vitro and in vivo release studies showed the controlled release of serratiopeptidase and clove oil for 24 h. Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) studies confirmed no interaction of serratiopeptidase and clove oil with polymers and excipients. It showed that buccal patch of emulsified clove oil with serratiopeptidase can be used for their controlled delivery in toothache or dental pain.