Anis Daou*
The discovery of vaccines has had positive effects in decreasing the incidence of worldwide infectious diseases. Despite these achievements, a decline in vaccine confidence threatens to reverse these accomplishments to date. Restoring confidence is therefore paramount towards promoting timely and effective intervention for diseases. Most recently, Severe Acute Respiratory Syndrome Corona-Virus (SARS-CoV-2) has consumed and crippled the world’s population, impacting the health of hundreds of millions. Vaccine hesitancy continues to be pervasive amongst the worldwide public who harbor significant doubt towards both Pharmaceutical and Governmental authorities. This article takes a detailed look into the history and mechanisms of the four most commonly used vaccines for SARS-CoV-2 – namely Pfizer/BioNTech; AstraZeneca/Oxford; Sputnik and Moderna – providing critical analysis of published data, dissecting and appraising the clinical trials in detail and combining all those findings into this review. This article also addresses common misconceptions about these vaccines and other innoculations in general.