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Abstracto

Protein S Deficiency Presenting with Hemorrhage in a Term Neonate

Fairouz Ayari, Takoua Bensmail, Essid Latifa, Wiem Barbaria and Samia Kacem

Unexplained bleeding symptoms in otherwise healthy full-term usually present a diagnostic challenge for treating physicians requiring prompt and accurate laboratory investigations to ensure appropriate treatment and possibly avoid long-term morbidity. We report a case of a term neonate with severe protein S deficiency manifested by systemic hemorrhage and multiple organ failure at 9 days of age. We review how protein S influences the coagulation and the fibrinolytic pathways, discussing therapeutic approaches of neonates with purpura fulminans.