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Abstracto
Simultaneous estimation of metformin hydrochloride and alpha lipoic acid by hptlc method in tablet dosage form
Patel Prachi Jitendra*, Madhuri Hinge
High Performance Thin Layer Chromatographic Method has been developed to quantify Metformin Hydrochloride and Alpha Lipoic Acid. Separation of both the drugs was carried out by using silica gel 60F254 plates. The mobile phase comprised of Toluene, Ammonium Acetate (4%), Ethyl Acetate (5:4:1 v/v/v). The detection wavelength was found to be 227 nm. The Rf values of Metformin Hydrochloride and Alpha Lipoic Acid were found to be 0.28 and 0.65 respectively. The method was linear over concentration range 1500-7500 ng /band for Metformin Hydrochloride and 600-3000 ng / band for Alpha Lipoic Acid. The developed method was validated according to ICH guidelines. Linearity, regression value, recovery and %RSD of Intraday and interlay precision values were found within the limits and the method was found to be satisfactory. The developed HPTLC method was found to be simple, accurate and precise.