Revista de investigación e informes de tumores

Abstracto

Study of hematopoietic microenvironment in some blood disorders particularly in malignant hematopoietic diseases

Ahmad Reza Rahnemoon

Hematopoietic neoplasms are known or assumed to be clonal processes arising as the result of genetic errors. But I think some other items should be involved in these neoplasms too. As we know, hematopoietic stem cells (HSCs) are classified as important stem cells due to their ability to differentiate to the cells including the lineages of lymphoid and myeloid cells. Lymphoid cell lineage includes T and B cells while granulocytes, monocytes, erythrocytes, megakaryocytes belong to the lineage of myeloid. Hematopoiesis, is controlled by several complex interactions between genetic processes in blood progenitor cells and bone marrow microenvironment as an important regulator in this matter. Thus, we must understand how malignancy disrupts the normal mechanisms of hematopoiesis which controlling HSC function and blood production? In the past decades, the theoretical concept of a stem cell microenvironment was proposed and its structure is called HSC niche described which the existence of niche includes regulating in function of HSC and its differentiation